INTRODUCTION: The increasing incidence of mental illnesses and neurodegenerative diseases results in a high demand for drugs targeting the central nervous system (CNS). These drugs easily reach the CNS, have a high affinity for CNS targets, and are prone to cause seizures as an adverse drug reaction. Current seizure liability assessment heavily depends on in vivo or ex vivo animal models and is therefore ethically debated, labor intensive, expensive, and not always predictive for human risk. AREAS COVERED: The demand for CNS drugs urges the development of alternative safety assessment strategies. Yet, the complexity of the CNS hampers reliable detection of compound-induced seizures. This review provides an overview of the requirements of in...
The current testing requirements for both adult and developmental neurotoxicity evaluation are based...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
Prediction of neurotoxic effects is a key feature in the toxicological profile of many compounds and...
INTRODUCTION: The increasing incidence of mental illnesses and neurodegenerative diseases results in...
The brain is the most complex organ in the body, controlling our highest functions, as well as regul...
Worldwide more and more people depend on medication for mental or neurodegenerative diseases, thereb...
In the framework of the IMI2-NeuroDeRisk consortium, three in vitro electrophysiology assays were co...
Drug-induced seizure is a major reason for compound attrition during drug development, hence testing...
Seizures are life-threatening adverse drug reactions which are investigated late in drug development...
Regulatory guidelines recommend specialised safety pharmacology assessments in animals to characteri...
There is a gap in knowledge when it comes to the effects of chemicals on human health. In particular...
Detection and characterization of chemical-induced toxic effects in the central and peripheral nervo...
AbstractBackground: There is a need to discover novel chemical compounds that will inhibit the patho...
AbstractAdverse CNS effects account for a sizeable proportion of all drug attrition cases. These adv...
Currently, the identification of chemicals that have the potential to induce developmental neurotoxi...
The current testing requirements for both adult and developmental neurotoxicity evaluation are based...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
Prediction of neurotoxic effects is a key feature in the toxicological profile of many compounds and...
INTRODUCTION: The increasing incidence of mental illnesses and neurodegenerative diseases results in...
The brain is the most complex organ in the body, controlling our highest functions, as well as regul...
Worldwide more and more people depend on medication for mental or neurodegenerative diseases, thereb...
In the framework of the IMI2-NeuroDeRisk consortium, three in vitro electrophysiology assays were co...
Drug-induced seizure is a major reason for compound attrition during drug development, hence testing...
Seizures are life-threatening adverse drug reactions which are investigated late in drug development...
Regulatory guidelines recommend specialised safety pharmacology assessments in animals to characteri...
There is a gap in knowledge when it comes to the effects of chemicals on human health. In particular...
Detection and characterization of chemical-induced toxic effects in the central and peripheral nervo...
AbstractBackground: There is a need to discover novel chemical compounds that will inhibit the patho...
AbstractAdverse CNS effects account for a sizeable proportion of all drug attrition cases. These adv...
Currently, the identification of chemicals that have the potential to induce developmental neurotoxi...
The current testing requirements for both adult and developmental neurotoxicity evaluation are based...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
Prediction of neurotoxic effects is a key feature in the toxicological profile of many compounds and...