Avian influenza viruses (AIVs) recognize sialic acid linked α2,3 to galactose (SAα2,3Gal) glycans as receptors. In this study, the interactions between hemagglutinins (HAs) of AIVs and sulfated SAα2,3Gal glycans were analyzed to clarify the molecular basis of interspecies transmission of AIVs from ducks to chickens. It was revealed that E190V and N192D substitutions of the HA increased the recovery of viruses derived from an H6 duck virus isolate, A/duck/Hong Kong/960/1980 (H6N2), in chickens. Recombinant HAs from an H6 chicken virus, A/chicken/Tainan/V156/1999 (H6N1), bound to sulfated SAα2,3Gal glycans, whereas the HAs from an H6 duck virus did not. Binding preference of mutant HAs revealed that an E190V substitution is critical for the r...
AbstractAvian influenza viruses possess hemagglutinin (HA) which preferentially bind to the sialic a...
Background. Influenza A viruses of domestic birds originate from the natural reservoir in aquatic bi...
AbstractReceptor specificity of influenza A/H5 viruses including human 2003–04 isolates was studied....
Avian influenza viruses (AIVs) recognize sialic acid linked α2,3 to galactose (SAα2,3Gal) glycans as...
Influenza viruses isolated from ducks are rarely able to infect chickens; it is therefore postulated...
It is commonly accepted that avian influenza viruses (AIVs) bind to terminal a2,3 sialic acid (SA) r...
AbstractInfluenza viruses recognize sialoglycans as receptors. Although viruses isolated form chicke...
AbstractTo characterize differences in the receptor-binding specificity of H5N1 chicken viruses and ...
Wild birds are the natural reservoirs of Influenza A viruses (IAVs) which cause occasional pandemics...
AbstractTo identify the molecular determinants contributing to the inability of recent human influen...
Avian influenza viruses are considered to be key contributors to the emergence of human influenza pa...
It is commonly accepted that avian influenza viruses (AIVs) bind to terminal \uce\ub12,3 sialic acid...
Highly pathogenic avian influenza viruses (HPAIVs) of hemagglutinin H5 and H7 subtypes emerge after ...
AbstractWe have determined the structure of the HA of an avian influenza virus, A/duck/Ukraine/63, a...
Clade 2.3.4.4 avian H5Ny viruses, namely H5N2, H5N6, and H5N8, have exhibited unprecedented intercon...
AbstractAvian influenza viruses possess hemagglutinin (HA) which preferentially bind to the sialic a...
Background. Influenza A viruses of domestic birds originate from the natural reservoir in aquatic bi...
AbstractReceptor specificity of influenza A/H5 viruses including human 2003–04 isolates was studied....
Avian influenza viruses (AIVs) recognize sialic acid linked α2,3 to galactose (SAα2,3Gal) glycans as...
Influenza viruses isolated from ducks are rarely able to infect chickens; it is therefore postulated...
It is commonly accepted that avian influenza viruses (AIVs) bind to terminal a2,3 sialic acid (SA) r...
AbstractInfluenza viruses recognize sialoglycans as receptors. Although viruses isolated form chicke...
AbstractTo characterize differences in the receptor-binding specificity of H5N1 chicken viruses and ...
Wild birds are the natural reservoirs of Influenza A viruses (IAVs) which cause occasional pandemics...
AbstractTo identify the molecular determinants contributing to the inability of recent human influen...
Avian influenza viruses are considered to be key contributors to the emergence of human influenza pa...
It is commonly accepted that avian influenza viruses (AIVs) bind to terminal \uce\ub12,3 sialic acid...
Highly pathogenic avian influenza viruses (HPAIVs) of hemagglutinin H5 and H7 subtypes emerge after ...
AbstractWe have determined the structure of the HA of an avian influenza virus, A/duck/Ukraine/63, a...
Clade 2.3.4.4 avian H5Ny viruses, namely H5N2, H5N6, and H5N8, have exhibited unprecedented intercon...
AbstractAvian influenza viruses possess hemagglutinin (HA) which preferentially bind to the sialic a...
Background. Influenza A viruses of domestic birds originate from the natural reservoir in aquatic bi...
AbstractReceptor specificity of influenza A/H5 viruses including human 2003–04 isolates was studied....