EFFECTS OF ADJUNCTIVE LOCAL OR SYSTEMIC METRONIDAZOLE WITH NON-SURGICAL PERIODONTAL THERAPY ON PERIODONTAL CLINICAL PARAMETERS AND GINGIVAL CREVICULAR FLUID BIOMARKERS

Objective: The (Aim of this study was to investigate the effects of local or systemic metronidazole as adjunctives to non-surgical periodontal treatment. on the clinical parameters and gingival crevicular fluid (GCE) levels of matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in chronic periodontitis patients. Material and Method: Thirty patients were allocated into 3 groups: 10 were treated with scaling and root planing (SRP) only; 10 were treated with SRP and received adjunctive local metronidazole; 10 were treated with SRP and received adjunctive systemic metronidazole. Periodontal clinical parameters including plaque index, sulcus bleeding index, probing depth and relative attachment level were recorded before and after the treatments. The MMP-8 and TIMP-1 levels in GCF samples collected on days 0 and 49 were determined by using the enzyme-linked immunosorbent assay Results: All groups showed significant reductions in plaque index, sulcus bleeding index and probing depth (p<0.01.). Although attachment gain was observed in all groups, only the gain in the SRP plus local metronidazole group was significant (p<0.05). The GCF MMP-8 levels decreased significantly (p