Association of Macrophage Migration Inhibitory FactorGene - 173 G/C Polymorphism with Occurrence andSeverity of Acute Pancreatitis

Introduction: Promoter polymorphism -173G/C of macrophage migration inhibitory factor (MIF) is related to higher MIF levels. In this study, we have investigated the effects of this polymorphism with the occurrence and severity of acute pancreatitis (AP).Methods: Sixty-two AP patients and 83 healthy volunteers were included in our study. The demographical, clinical, labora-tory and radiological findings were recorded, and peripheral blood samples were genetically analyzed.Results: In this study, 35 female and 27 male patients were included. The mean age was 51. The AP severity was mild at 37 patients, moderate at 21 and severe at four patients. Genotype and allelic distribution at patient and control groups were statistically different (p