Serum leptin concentration in children with chronic renal failure

Objective: Various factors are responsible for uremic anorexia. Increase in serum leptin levels and uremic toxins stimulate melanocortin hormone receptors to increase energy consumption and reduce food intake. In this study, we investigated renal excretion of leptin by comparing serum leptin concentrations of healthy controls, and children with chronic renal failure.& para;& para;Methods: Serum leptin, leptin / BMI, albumin, glucose, creatinine, urea, triglyceride and cholesterol levels were eveluated in a total of 33 pediatric patients followed up for chronic renal failure and 29 healthy children in the control group.& para;& para;Results: Serum leptin levels (18.49 +/- 28.55) and leptin / BMI (0.94 +/- 1.36) in female patients were higher than leptin (7.73 +/- 5.65) and leptin / BMI (0.39 +/- 0.25) in the control group (p>0.05). In male patients, serum leptin levels (1.48 +/- 1.36; 4.88 +/- 3.70) and leptin/ BMI (0.08 +/- 0.081; 0.25 +/--0.16) were found to be lower than those of the control group (p