Peptide nucleic acids (PNAs) have been demonstrated to be very useful tools for gene regulation at different levels and with different mechanisms of action. In the last few years the use of PNAs for targeting microRNAs (anti-miRNA PNAs) has provided impressive advancements. In particular, targeting of microRNAs involved in the repression of the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which is defective in cystic fibrosis (CF), is a key step in the development of new types of treatment protocols. In addition to the anti-miRNA therapeutic strategy, inhibition of miRNA functions can be reached by masking the miRNA binding sites present within the 3′UTR region of the target mRNAs. The objective of this...
Since the demonstration that microRNAs are deeply involved in the regulation of Cystic Fibrosis (CF)...
We read with great interest the article titled “MicroRNA-145 Antagonism Reverses TGF-b Inhibition of...
(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR)...
Peptide nucleic acids (PNAs) have been demonstrated to be very useful tools for gene regulation at d...
Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in p...
Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in p...
Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in p...
The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacolo...
Since the identification of microRNAs (miRNAs) involved in the regulation of Cystic Fibrosis Transme...
Cystic Fibrosis (CF) is one of the most common life shortening conditions in Caucasians. CF is cause...
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encodes for a chloride channel d...
Cystic Fibrosis (CF) is the most common lethal genetic disorder among Caucasians. Several studies de...
(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR)...
Recently, microRNAs (miRNAs) were identified able to inhibit the expression of the Cystic Fibrosis T...
MicroRNAs (miRNAs) are small non-coding RNAs involved in regulation of gene expression. They bind in...
Since the demonstration that microRNAs are deeply involved in the regulation of Cystic Fibrosis (CF)...
We read with great interest the article titled “MicroRNA-145 Antagonism Reverses TGF-b Inhibition of...
(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR)...
Peptide nucleic acids (PNAs) have been demonstrated to be very useful tools for gene regulation at d...
Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in p...
Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in p...
Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in p...
The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacolo...
Since the identification of microRNAs (miRNAs) involved in the regulation of Cystic Fibrosis Transme...
Cystic Fibrosis (CF) is one of the most common life shortening conditions in Caucasians. CF is cause...
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encodes for a chloride channel d...
Cystic Fibrosis (CF) is the most common lethal genetic disorder among Caucasians. Several studies de...
(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR)...
Recently, microRNAs (miRNAs) were identified able to inhibit the expression of the Cystic Fibrosis T...
MicroRNAs (miRNAs) are small non-coding RNAs involved in regulation of gene expression. They bind in...
Since the demonstration that microRNAs are deeply involved in the regulation of Cystic Fibrosis (CF)...
We read with great interest the article titled “MicroRNA-145 Antagonism Reverses TGF-b Inhibition of...
(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR)...