Neuroprotective and other functional proteins of mitochondria were quantified in extracts of plasma neural-derived exosomes from ten first-episode psychosis (FP) patients and ten matched psychiatrically normal controls (ctls). Astrocyte-derived extracellular vesicles (ADEVs) and neuron-derived extracellular vesicles (NDEVs) were immunoabsorbed separately from physically precipitated plasma total EVs. Extracted mitochondrial ATP synthase was specifically immunofixed to plastic wells for quantification of catalytic activity based on conversion of NADH to NAD+ . Other extracted mitochondrial functional proteins were quantified by ELISAs. All protein levels were normalized with EV content of the CD81 exosome marker. FP patient ADEV level but no...
In-vivo imaging studies and post-mortem studies have demonstrated an impairment of energy metabolism...
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schiz...
Mitochondria are ancient endosymbiotic double membrane organelles that support a wide range of eukar...
Neuroprotective and other functional proteins of mitochondria were quantified in extracts of plasma ...
Potentially neurotoxic systems involved in traumatic and degenerative diseases of the brain were ass...
To characterize neuronal mitochondrial abnormalities in major depressive disorder (MDD), functional ...
Early detection and intervention in schizophrenia requires mechanism-based biomarkers that capture n...
Gene expression has been studied in post-mortem frontal cortex samples from patients who had suffere...
Extracellular vesicles (EVs) are cell-derived structures that transport proteins, lipids and nucleic...
Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding ...
The etiology and pathophysiology of schizophrenia remain unknown. A parallel transcriptomics, proteo...
Schizophrenia (SCZ) is a chronic brain disease. Early detection and treatment are associated with im...
Correct neuronal function is an energy costly process, highly dependent upon the ATP production and ...
Extracellular vesicles (EVs) are cell-derived structures that transport proteins, lipids and nucleic...
In-vivo imaging studies and post-mortem studies have demonstrated an impairment of energy metabolism...
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schiz...
Mitochondria are ancient endosymbiotic double membrane organelles that support a wide range of eukar...
Neuroprotective and other functional proteins of mitochondria were quantified in extracts of plasma ...
Potentially neurotoxic systems involved in traumatic and degenerative diseases of the brain were ass...
To characterize neuronal mitochondrial abnormalities in major depressive disorder (MDD), functional ...
Early detection and intervention in schizophrenia requires mechanism-based biomarkers that capture n...
Gene expression has been studied in post-mortem frontal cortex samples from patients who had suffere...
Extracellular vesicles (EVs) are cell-derived structures that transport proteins, lipids and nucleic...
Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding ...
The etiology and pathophysiology of schizophrenia remain unknown. A parallel transcriptomics, proteo...
Schizophrenia (SCZ) is a chronic brain disease. Early detection and treatment are associated with im...
Correct neuronal function is an energy costly process, highly dependent upon the ATP production and ...
Extracellular vesicles (EVs) are cell-derived structures that transport proteins, lipids and nucleic...
In-vivo imaging studies and post-mortem studies have demonstrated an impairment of energy metabolism...
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schiz...
Mitochondria are ancient endosymbiotic double membrane organelles that support a wide range of eukar...