Emerging studies suggest that tumor-cell-intrinsic factors contribute to the level of immune infiltration into the tumors and the tumor immune escape. Therefore, it is critical to understand the relationship between tumor-cell-intrinsic factors and the immune response. High-mobility group box protein 1 (HMGB1) is a protein with diverse roles both in the intracellular and extracellular environments. In cancer, HMGB1 manifests both protumoral and antitumoral properties. Yet, it is not clear if the tumor-cell-intrinsic roles of HMGB1 influence immune cell infiltration in tumors. In this thesis, we demonstrated that downregulation of HMGB1 in cancer cells reduced the tumor growth in mice and led to a local reprogramming of the tumor microenviro...
Background: High mobility group box (HMGB) proteins are DNA chaperones involved in transcription, DN...
Abstract: High mobility group box 1 (HMGB1) is one of the recently defined damage-associated mo-lecu...
Background: High-mobility group box-1 (HMGB1) is involved in the tumorigenesis and metastasis of var...
Emerging studies suggest that tumor-cell-intrinsic factors contribute to the level of immune infiltr...
Chronic inflammation often precedes malignant transformation and later drives tumor progression. Lik...
High mobility group box 1 (HMGB1) is a member of the “danger associated molecular patterns” (DAMPs) ...
High mobility group box 1 (HMGB1) is a nuclear protein first discovered nearly 30 years ago. It was ...
Introduction Glucose depravation, hypoxia, and acidosis are characteristic features of the central c...
HMGB1 is a ubiquitously expressed intracellular protein that binds DNA and transcription factors and...
Simona Martinotti, Mauro Patrone, Elia Ranzato DiSIT – Dipartimento di Scienze e Innovazione T...
High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly i...
HMGBl is an abundant and ubiquitously expressed non-histone nuclear protein. HMGB1 is a nuclear arch...
Glucose deprivation, hypoxia and acidosis are characteristic features of the central core of most so...
Purpose: High mobility group box (HMGB) proteins are nuclear nonhistone chromosomalproteins that ben...
subcellular localization of HMGB1, a chromatin protein with a cytokine function (Minisymposium). J I...
Background: High mobility group box (HMGB) proteins are DNA chaperones involved in transcription, DN...
Abstract: High mobility group box 1 (HMGB1) is one of the recently defined damage-associated mo-lecu...
Background: High-mobility group box-1 (HMGB1) is involved in the tumorigenesis and metastasis of var...
Emerging studies suggest that tumor-cell-intrinsic factors contribute to the level of immune infiltr...
Chronic inflammation often precedes malignant transformation and later drives tumor progression. Lik...
High mobility group box 1 (HMGB1) is a member of the “danger associated molecular patterns” (DAMPs) ...
High mobility group box 1 (HMGB1) is a nuclear protein first discovered nearly 30 years ago. It was ...
Introduction Glucose depravation, hypoxia, and acidosis are characteristic features of the central c...
HMGB1 is a ubiquitously expressed intracellular protein that binds DNA and transcription factors and...
Simona Martinotti, Mauro Patrone, Elia Ranzato DiSIT – Dipartimento di Scienze e Innovazione T...
High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly i...
HMGBl is an abundant and ubiquitously expressed non-histone nuclear protein. HMGB1 is a nuclear arch...
Glucose deprivation, hypoxia and acidosis are characteristic features of the central core of most so...
Purpose: High mobility group box (HMGB) proteins are nuclear nonhistone chromosomalproteins that ben...
subcellular localization of HMGB1, a chromatin protein with a cytokine function (Minisymposium). J I...
Background: High mobility group box (HMGB) proteins are DNA chaperones involved in transcription, DN...
Abstract: High mobility group box 1 (HMGB1) is one of the recently defined damage-associated mo-lecu...
Background: High-mobility group box-1 (HMGB1) is involved in the tumorigenesis and metastasis of var...