402.5: Human Amniotic Epithelial Cells Immunomodulatory Properties Protect Islets Against Inflammatory Cytokines In Vitro
- Lebreton, Fanny
- Bellofatto, Kevin
- Wassmer, Charles-Henri
- Perez, Lisa Laura
- Khatri, Rahul
- Hasany, Masoud
- Hanna, Reine
- Oliveira Almeida Fonseca, Laura Do Mar
- Cottet-Dumoulin, David
- Parnaud, Géraldine
- Bosco, Domenico
- Berney, Thierry
- Berishvili Berney, Ekaterine
Publication date
January 2021
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
Inflammation is a primary contributor to early graft loss and poor islet engraftment. Human amniotic epithelial cells (hAEC) possess regenerative, immunomodulatory and anti-inflammatory properties. In particular, these cells express HLA-G and HLA-E, involved in immunomodulation and immune tolerance. Here, we hypothesized that hAECs could protect islets from cellular damage induced by proinflammatory cytokines and we assessed the cytokine-induced expression of HLA-G and HLA-E in hAECs
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