The Effect of Single Type Black Garlic (Allium sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus norvegicus) Models of Diabetes Mellitus

Diabetes Mellitus cause oxidative stress. Oxidative stress is the main contributor of the pathogenesis of tubular damage. Black garlic (Allium sativum L) contain antioxidant such as polyphenol and flavonoid can regenerate the cell of Langerhans islets and the kidney tubular in rats with diabetes mellitus model. To indentify the effect of black garlic (Allium sativum L.) extract on the cell of Langerhans islets and the kidney tubular microscopy in rats models of diabetes mellitus. This research is True Experimental with post-test only control group design. The samples were divided into 4 groups. Control group was given alloxan 24 mg/0,3 ml, group 1, 2, and 3 were given 24 mg/0,3ml and black garlic (Allium sativum L.) extracts at dose 0,15, 0,3, and 0,6 (ml/200gBW/day). Treatment was given orally per day within 14 days. Statistical analysis used Post Hoc and t-test. Results was found significant of differences (p