In multicellular organisms, a relatively small number of highly conserved signaling pathways are used to enable intercellular communication. While the underlying molecular components and interactions are increasingly well understood, a fundamental mystery is how the diverse cell types of the body can be so precisely coordinated by so few pathways. It has long been known that different cell types exhibit varied responses to molecular signals, and it is unclear how this cell type specificity arises. In this work, we take a different perspective on this question and explore how cell type specificity can be generated at the level of intracellular signal. We refer to this ability to selectively activate different cell types as "addressing." By e...
Bone Morphogenetic Proteins (BMPs) are extracellular messenger ligands involved in controlling a wid...
<div><p>Many proteins and signaling pathways are present in most cell types and tissues and yet perf...
Background: Transforming growth factor (TGF)β superfamily members transduce signals by oligomerizing...
In multicellular organisms, secreted ligands selectively activate, or "address," specific target cel...
Cell-cell communication systems typically comprise families of ligand and receptor variants that fun...
The bone morphogenetic protein (BMP) signaling pathway comprises multiple ligands and receptors that...
Bone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)-β and Activins/In...
AbstractBone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)-β and Act...
Evolution generated diverse signaling proteins for the control of multicellular patterns and organ- ...
Cells use a variety of different mechanisms to sense and respond to the constantly changing environm...
International audienceMembers of the bone morphogenetic protein (BMP) family of ligands have been id...
Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization c...
Bone Morphogenetic Proteins (BMPs) are important growth factors that regulate many cellular processe...
Cellular signaling is an area of intense research that transcends all fields of experimental biology...
SummaryIn the developing organism, cells differentiate, divide and die as part of groups of hundreds...
Bone Morphogenetic Proteins (BMPs) are extracellular messenger ligands involved in controlling a wid...
<div><p>Many proteins and signaling pathways are present in most cell types and tissues and yet perf...
Background: Transforming growth factor (TGF)β superfamily members transduce signals by oligomerizing...
In multicellular organisms, secreted ligands selectively activate, or "address," specific target cel...
Cell-cell communication systems typically comprise families of ligand and receptor variants that fun...
The bone morphogenetic protein (BMP) signaling pathway comprises multiple ligands and receptors that...
Bone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)-β and Activins/In...
AbstractBone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)-β and Act...
Evolution generated diverse signaling proteins for the control of multicellular patterns and organ- ...
Cells use a variety of different mechanisms to sense and respond to the constantly changing environm...
International audienceMembers of the bone morphogenetic protein (BMP) family of ligands have been id...
Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization c...
Bone Morphogenetic Proteins (BMPs) are important growth factors that regulate many cellular processe...
Cellular signaling is an area of intense research that transcends all fields of experimental biology...
SummaryIn the developing organism, cells differentiate, divide and die as part of groups of hundreds...
Bone Morphogenetic Proteins (BMPs) are extracellular messenger ligands involved in controlling a wid...
<div><p>Many proteins and signaling pathways are present in most cell types and tissues and yet perf...
Background: Transforming growth factor (TGF)β superfamily members transduce signals by oligomerizing...