Background and objective: Tigecycline, a broad-spectrum glycylcycline antibiotic, is approved for use at a fixed dose irrespective of body weight. However, its pharmacokinetics may be altered in obesity, which would impact on the antibiotic's effectiveness. The objective of this study was to investigate the plasma and subcutaneous tissue concentrations of tigecycline in obese patients compared with those in a non-obese control group. Methods: Fifteen obese patients (one class II and 14 class III) undergoing bariatric surgery and 15 non-obese patients undergoing intra-abdominal surgery (mainly tumour resection) received a single dose of 50 or 100 mg tigecycline as an intravenous short infusion. Tigecycline concentrations were measured up ...
Tissue penetration of systemic antibiotics is an important consideration for positive outcomes in di...
Mohamed M Ibrahim,1 Abdulla M Abuelmatty,2 Gehan H Mohamed,3 Mohsen A Nasr,4 Amal K Hussein,5 Mohy E...
OBJECTIVES: Obesity may alter the pharmacokinetics of β -lactams. The goal of this study was to eval...
Background and objective: Tigecycline, a broad-spectrum glycylcycline antibiotic, is approved for us...
Background: Pharmacokinetic (PK) and pharmacodynamic (PD) data on perioperative antibiotic prophyl...
Objectives: To assess the pharmacokinetics and tissue penetration of fosfomycin in obese and non-obe...
BACKGROUND AND OBJECTIVE: Gentamicin is an aminoglycoside antibiotic predominantly used in bloodstre...
Item does not contain fulltextOBJECTIVES: As morbidly obese patients are prone to surgical site infe...
Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and ...
International audienceThe optimal dose of cefoxitin for antibiotic prophylaxis in obese patients rem...
Background: Linezolid is used for the treatment of soft tissue infections in critically ill patients...
AIMS: For vancomycin treatment in obese patients, there is no consensus on the optimal dose that wil...
PURPOSE: Tobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates with effic...
Objectives: The aim was to characterize linezolid population pharmacokinetics in plasma and intersti...
Precision dosing of piperacillin/tazobactam in obese patients is compromised by sparse information o...
Tissue penetration of systemic antibiotics is an important consideration for positive outcomes in di...
Mohamed M Ibrahim,1 Abdulla M Abuelmatty,2 Gehan H Mohamed,3 Mohsen A Nasr,4 Amal K Hussein,5 Mohy E...
OBJECTIVES: Obesity may alter the pharmacokinetics of β -lactams. The goal of this study was to eval...
Background and objective: Tigecycline, a broad-spectrum glycylcycline antibiotic, is approved for us...
Background: Pharmacokinetic (PK) and pharmacodynamic (PD) data on perioperative antibiotic prophyl...
Objectives: To assess the pharmacokinetics and tissue penetration of fosfomycin in obese and non-obe...
BACKGROUND AND OBJECTIVE: Gentamicin is an aminoglycoside antibiotic predominantly used in bloodstre...
Item does not contain fulltextOBJECTIVES: As morbidly obese patients are prone to surgical site infe...
Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and ...
International audienceThe optimal dose of cefoxitin for antibiotic prophylaxis in obese patients rem...
Background: Linezolid is used for the treatment of soft tissue infections in critically ill patients...
AIMS: For vancomycin treatment in obese patients, there is no consensus on the optimal dose that wil...
PURPOSE: Tobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates with effic...
Objectives: The aim was to characterize linezolid population pharmacokinetics in plasma and intersti...
Precision dosing of piperacillin/tazobactam in obese patients is compromised by sparse information o...
Tissue penetration of systemic antibiotics is an important consideration for positive outcomes in di...
Mohamed M Ibrahim,1 Abdulla M Abuelmatty,2 Gehan H Mohamed,3 Mohsen A Nasr,4 Amal K Hussein,5 Mohy E...
OBJECTIVES: Obesity may alter the pharmacokinetics of β -lactams. The goal of this study was to eval...