Anomalous aggregation of the neuronal protein α-Synuclein (α-Syn) is a pathological hallmark of Parkinson’s Disease (PD). Despite its strong link to PD and other synucleinopathies, the precise molecular mechanisms that facilitate α-Syn aggregation leading to neurodegeneration have yet to be elucidated. Here, we find that elevations in α-Syn lead to an increase in the plasma membrane (PM) phosphoinositide PI(4,5)P2, which precipitates α-Syn aggregation and drives toxic increases in mitochondrial Ca2+ and reactive oxygen species leading to neuronal death in PD. Upstream of this deleterious signaling pathway is PIP5K1γ, whose abundance and localization is enhanced at the PM by α-Syn-dependent increases in PLK1 activity. Selectively inhibiting ...
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic...
\ua9 2018 International Parkinson and Movement Disorder Society Parkinson\u27s disease and other syn...
The aggregation of α-synuclein (α-syn) is a major factor behind the onset of Parkinson’s disease (PD...
Anomalous aggregation of the neuronal protein α-Synuclein (α-Syn) is a pathological hallmark of Park...
α-Synuclein (α-syn), is a self-aggregating protein that has been identified as a pathologically impo...
Abstract Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates o...
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and misfolded α-...
The abnormal aggregation of fibrillar α-synuclein in Lewy bodies plays a critical role in the pathog...
Exposure of cultured primary neurons to preformed α-synuclein fibrils (PFFs) leads to the recruitmen...
α-Synuclein (α-Syn) is intimately linked to the etiology of Parkinson's Disease, as mutations and ev...
Phosphorylation of the α-synuclein (α-syn) protein at Ser129 [P(S129)-α-] was found to be the most a...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
International audienceCurrent therapeutic strategies are centered on the dopaminergic system, with l...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
The aggregation of α-synuclein (α-syn) is a major factor behind the onset of Parkinson’s disease (PD...
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic...
\ua9 2018 International Parkinson and Movement Disorder Society Parkinson\u27s disease and other syn...
The aggregation of α-synuclein (α-syn) is a major factor behind the onset of Parkinson’s disease (PD...
Anomalous aggregation of the neuronal protein α-Synuclein (α-Syn) is a pathological hallmark of Park...
α-Synuclein (α-syn), is a self-aggregating protein that has been identified as a pathologically impo...
Abstract Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates o...
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and misfolded α-...
The abnormal aggregation of fibrillar α-synuclein in Lewy bodies plays a critical role in the pathog...
Exposure of cultured primary neurons to preformed α-synuclein fibrils (PFFs) leads to the recruitmen...
α-Synuclein (α-Syn) is intimately linked to the etiology of Parkinson's Disease, as mutations and ev...
Phosphorylation of the α-synuclein (α-syn) protein at Ser129 [P(S129)-α-] was found to be the most a...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
International audienceCurrent therapeutic strategies are centered on the dopaminergic system, with l...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
The aggregation of α-synuclein (α-syn) is a major factor behind the onset of Parkinson’s disease (PD...
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic...
\ua9 2018 International Parkinson and Movement Disorder Society Parkinson\u27s disease and other syn...
The aggregation of α-synuclein (α-syn) is a major factor behind the onset of Parkinson’s disease (PD...