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Nanotemplating of biodegradable polymer membranes for constant-rate drug delivery.

  • Bernards, Daniel A
  • Desai, Tejal A
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Publication date
June 2010
Publisher
eScholarship, University of California

Abstract

(Figure Presented) A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic biocompatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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