Add to ORKGTDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. As TDP-43 inclusions have recently been described in the muscle of inclusion body myositis patients, this highlights the need to understand the role of TDP-43 beyond the central nervous system. Using RNA-seq, we directly compare TDP-43-mediated RNA processing in muscle (C2C12) and neuronal (NSC34) mouse cells. TDP-43 displays a cell-type-characteristic behaviour targeting unique transcripts in each cell-type, which is due to characteristic expression of RNA-binding proteins, that influence TDP-43's performance and define cell-type specific splicing. Among splicing events commonly dysre...
Abstract TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which partici...
TAR DNA-binding protein of 43 kDa (TDP-43) is the major component protein of inclusions found in bra...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
TAR DNA-binding protein 43, mostly referred to as TDP-43 (encoded by the TARDBP gene) is strongly li...
TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal ...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Aggregation of the RNA-binding protein TAR DNA-binding protein 43 (TDP-43) is the key neuropathologi...
43) is a major protein component within ubiquitin-positive inclusions of frontotemporal lobar degene...
TAR DNA binding protein-43 (TDP-43) is found in ubiquitinated inclusions (UBIs) in some frontotempor...
Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontote...
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sc...
Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontote...
Abstract Background Redistribution of nuclear TAR DNA binding protein 43 (TDP-43) to the cytoplasm a...
Abstract TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which partici...
TAR DNA-binding protein of 43 kDa (TDP-43) is the major component protein of inclusions found in bra...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
TAR DNA-binding protein 43, mostly referred to as TDP-43 (encoded by the TARDBP gene) is strongly li...
TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal ...
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weaknes...
Aggregation of the RNA-binding protein TAR DNA-binding protein 43 (TDP-43) is the key neuropathologi...
43) is a major protein component within ubiquitin-positive inclusions of frontotemporal lobar degene...
TAR DNA binding protein-43 (TDP-43) is found in ubiquitinated inclusions (UBIs) in some frontotempor...
Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontote...
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sc...
Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontote...
Abstract Background Redistribution of nuclear TAR DNA binding protein 43 (TDP-43) to the cytoplasm a...
Abstract TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which partici...
TAR DNA-binding protein of 43 kDa (TDP-43) is the major component protein of inclusions found in bra...
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amy...