Neural crest (NC) cells migrate throughout vertebrate embryos to give rise to a huge variety of cell types, but when and where lineages emerge and their regulation remain unclear. We have performed single-cell RNA sequencing (RNA-seq) of cranial NC cells from the first pharyngeal arch in zebrafish over several stages during migration. Computational analysis combining pseudotime and real-time data reveals that these NC cells first adopt a transitional state, becoming specified mid-migration, with the first lineage decisions being skeletal and pigment, followed by neural and glial progenitors. In addition, by computationally integrating these data with RNA-seq data from a transgenic Wnt reporter line, we identify gene cohorts with similar tem...
The neural crest (NC) is an emblematic population of embryonic, stem-like cells characterised by the...
AbstractAfter induction and specification in the ectoderm, at the border of the neural plate, the ne...
The neural crest—a key innovation of the vertebrates—gives rise to diverse cell types including mela...
Neural crest (NC) cells migrate throughout vertebrate embryos to give rise to a huge variety of cell...
The neural crest is a migratory population of stem-like cells that contribute to multiple traits inc...
In embryonic development, tissues arise from multipotent progenitor populations and undergo lineage ...
Neural crest (NC) cell development is a complex, multistep process that begins with induction and sp...
The neural crest (NC) is a vertebrate-specific population of multipotent cells, often referred to as...
The bones in your face, the pigment in your skin and the neural circuitry that controls your digesti...
Complex multicellular organisms are composed of at least 200 cell types, which contain the same DNA ...
Neurogenesis comprises many highly regulated processes including proliferation, differentiation, and...
Craniofacial anomalies are a prominent issue in newborns. In order to study a possible cause for suc...
Cranial neural crest cells migrate in a precisely segmented manner to form cranial ganglia, facial s...
dissertationDirectional collective cell migration underlies diverse normal and pathological processe...
AbstractCranial neural crest cells migrate in a precisely segmented manner to form cranial ganglia, ...
The neural crest (NC) is an emblematic population of embryonic, stem-like cells characterised by the...
AbstractAfter induction and specification in the ectoderm, at the border of the neural plate, the ne...
The neural crest—a key innovation of the vertebrates—gives rise to diverse cell types including mela...
Neural crest (NC) cells migrate throughout vertebrate embryos to give rise to a huge variety of cell...
The neural crest is a migratory population of stem-like cells that contribute to multiple traits inc...
In embryonic development, tissues arise from multipotent progenitor populations and undergo lineage ...
Neural crest (NC) cell development is a complex, multistep process that begins with induction and sp...
The neural crest (NC) is a vertebrate-specific population of multipotent cells, often referred to as...
The bones in your face, the pigment in your skin and the neural circuitry that controls your digesti...
Complex multicellular organisms are composed of at least 200 cell types, which contain the same DNA ...
Neurogenesis comprises many highly regulated processes including proliferation, differentiation, and...
Craniofacial anomalies are a prominent issue in newborns. In order to study a possible cause for suc...
Cranial neural crest cells migrate in a precisely segmented manner to form cranial ganglia, facial s...
dissertationDirectional collective cell migration underlies diverse normal and pathological processe...
AbstractCranial neural crest cells migrate in a precisely segmented manner to form cranial ganglia, ...
The neural crest (NC) is an emblematic population of embryonic, stem-like cells characterised by the...
AbstractAfter induction and specification in the ectoderm, at the border of the neural plate, the ne...
The neural crest—a key innovation of the vertebrates—gives rise to diverse cell types including mela...