Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the RET proto-oncogene. We previously demonstrated that depletion of the mitochondrial molecular chaperone, mortalin, can effectively suppress human MTC cells in culture and in mouse xenografts, by disrupting mitochondrial bioenergetics and subsequently inducing apoptosis and RET downregulation. Similar effects were induced by MKT-077, a water-soluble rhodocyanine dye analog known to inhibit mortalin, but with notable toxicity in animals. These observations led us to evaluate recently developed MKT-077 analogs that exhibited higher selectivity to HSP70 proteins and improved bioavailability. We validated the MTC cell-suppressive effects of mortalin depl...
The family of 70-kDa proteins are molecular chaperones responsible for the noncovalent folding of ma...
Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and ina...
There is no effective treatment for recurrent or metastatic medullary thyroid carcinoma (MTC), a tum...
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the RET pr...
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the RET pr...
We previously reported that upregulation of mortalin (HSPA9/GRP75), the mitochondrial HSP70 chaperon...
BackgroundMedullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in ...
Mortalin is a chaperone protein that functions in many cellular processes such as mitochondrial biog...
The tumor suppressor protein, p53, is an important cell cycle regulator in humans. Over half of all ...
The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and mislocalized in ME...
The rhodacyanine, MKT-077, has antiproliferative activity against cancer cell lines through its abil...
Mortalin [also known as heat shock protein family A (HSP70) member 9 (HSPA9) or glucose-regulated pr...
Background: Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of ...
Restoration of deregulated apoptotic pathway is one of the main strategies for cancer therapeutics....
Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations i...
The family of 70-kDa proteins are molecular chaperones responsible for the noncovalent folding of ma...
Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and ina...
There is no effective treatment for recurrent or metastatic medullary thyroid carcinoma (MTC), a tum...
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the RET pr...
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the RET pr...
We previously reported that upregulation of mortalin (HSPA9/GRP75), the mitochondrial HSP70 chaperon...
BackgroundMedullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in ...
Mortalin is a chaperone protein that functions in many cellular processes such as mitochondrial biog...
The tumor suppressor protein, p53, is an important cell cycle regulator in humans. Over half of all ...
The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and mislocalized in ME...
The rhodacyanine, MKT-077, has antiproliferative activity against cancer cell lines through its abil...
Mortalin [also known as heat shock protein family A (HSP70) member 9 (HSPA9) or glucose-regulated pr...
Background: Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of ...
Restoration of deregulated apoptotic pathway is one of the main strategies for cancer therapeutics....
Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations i...
The family of 70-kDa proteins are molecular chaperones responsible for the noncovalent folding of ma...
Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and ina...
There is no effective treatment for recurrent or metastatic medullary thyroid carcinoma (MTC), a tum...