Add to ORKGEmerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This "dirty" mouse model offers a platform for studying acute transmission of viruses between and within hosts via natural mechanisms. We identified numerous viruses and other microbial species that transmit to cohoused mice, including prospective new members of the Coronaviridae, Astroviridae, Picornaviridae, and Narnaviridae families, and uncovered pathogen interactions that promote or prevent virus transmission. We also evaluated transmission dyn...
Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ...
The current worldwide outbreak of COVID-19 is associated with a novel coronavirus, SARS-CoV-2. This ...
ABSTRACT Novel pathogenic coronaviruses – including SARS-CoV and SARS-CoV-2 – arise by homologous re...
Emerging viruses threaten global health, but few experimental models can characterize the virus and ...
Rodents are recognized reservoir hosts for many human zoonotic pathogens. The current trends resulti...
Adventitious infections among rodents used in biomedical research and teaching continue to be proble...
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest percentage of li...
Bats are natural reservoirs of several important emerging viruses. Cross-species transmission appear...
Bats are natural reservoirs of several important emerging viruses. Cross-species transmission appear...
Two Old World rodents, house mice (Mus musculus) and Norway rats (Rattus norvegicus), were introduce...
The series of papers in this issue reflects the present state of knowledge on opportunistic infectio...
Accumulating studies show that the host microbiome influences the development or progression of many...
Laboratory mice are the most commonly used animal model for Staphylococcus aureus infection studies....
Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtype pose a major public health...
Mice (Mus musculus) are the most commonly used laboratory animals. Viral metagenomics on tissues of ...
Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ...
The current worldwide outbreak of COVID-19 is associated with a novel coronavirus, SARS-CoV-2. This ...
ABSTRACT Novel pathogenic coronaviruses – including SARS-CoV and SARS-CoV-2 – arise by homologous re...
Emerging viruses threaten global health, but few experimental models can characterize the virus and ...
Rodents are recognized reservoir hosts for many human zoonotic pathogens. The current trends resulti...
Adventitious infections among rodents used in biomedical research and teaching continue to be proble...
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest percentage of li...
Bats are natural reservoirs of several important emerging viruses. Cross-species transmission appear...
Bats are natural reservoirs of several important emerging viruses. Cross-species transmission appear...
Two Old World rodents, house mice (Mus musculus) and Norway rats (Rattus norvegicus), were introduce...
The series of papers in this issue reflects the present state of knowledge on opportunistic infectio...
Accumulating studies show that the host microbiome influences the development or progression of many...
Laboratory mice are the most commonly used animal model for Staphylococcus aureus infection studies....
Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtype pose a major public health...
Mice (Mus musculus) are the most commonly used laboratory animals. Viral metagenomics on tissues of ...
Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ...
The current worldwide outbreak of COVID-19 is associated with a novel coronavirus, SARS-CoV-2. This ...
ABSTRACT Novel pathogenic coronaviruses – including SARS-CoV and SARS-CoV-2 – arise by homologous re...