The Role of Nigella Sativa as Anti-Inflammation in Klebsiella Pneumonia Infection : A Review

The oil obtained from the seeds of Nigella sativa L. (N. sativa), also known as black cumin, is frequently used in the Mediterranean area for its anti-inflammatory. The essential oil of Nigella sativa (NSO) constituents include p-cymene, thymol, thymoquinone (TQ), dithymoquinone (DTQ) and thymohydroquinone (THQ). N. sativa and its main active constituent TQ have been attributed to numerous pharmacological activities. The present study demonstrated the anti-inflammatory effect of NSO in acute inflammation. Nigella sativa extract have an effect on very significant to degradation of colony amount of Klebsiella pneumoniae. Nigella sativa could be potential sources of antimicrobials with protective properties are attributed to reproducible radical scavenging activity as well as an interaction with numerous molecular targets involved in inflammation, including proinflammatory enzymes and cytokines. Furthermore, broad spectrum studies on specific cellular and molecular mechanisms of action as well as controlled clinical trials to prove its efficacy in humans are really needed to further assess the application of Nigella sativa