The Impact of Growth Hormone Treatment on Lipid Profile in Pediatric Growth-Hormone Deficiency

The lipid metabolism is not a stand-alone entity, and the hormonal involvement in this system appears of great importance. Growth hormone (GH) has a central role among the endocrine mediators, as demonstrated by studies in GH-deficient individuals. Atherogenic lipid profile is frequently described in these patients, and treatment intervention may help normalize them. Studies have revealed that gender and genetic polymorphism in genes involved in the growth process and metabolism may explain the variability of treatment responses. Until recently, hormonal substitution was used solely to improve final adult height, but there are indications that long-term treatment is advised and necessary to maintain adequate functionality of intermediary metabolism and protect from early cardiovascular disease morbidity and mortality