Industry 4.0 is moving forward under technology upgrades, utilizing information technology to improve the intelligence of the industry, whereas Industry 5.0 is value-driven, aiming to focus on essential societal needs, values, and responsibility. The manufacturing industry is currently moving towards the integration of productivity enhancements and sustainable human employment. Such a transformation has deeply changed the human–machine interaction (HMI), among which digital twin (DT) and extended reality (XR) are two cutting-edge technologies. A manufacturing DT offers an opportunity to simulate, monitor, and optimize the machine. In the meantime, XR empowers HMI in the industrial field. This paper presents an XR application framework for D...