Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe: associated factors and effect on mortality—a multicentre prospective cohort study
- Kraef C.
- Bentzon A.
- Panteleev A.
- Skrahina A.
- Bolokadze N.
- Tetradov S.
- Podlasin R.
- Karpov I.
- Borodulina E.
- Denisova E.
- Azina I.
- Lundgren J.
- Johansen I. S.
- Mocroft A.
- Podlekareva D.
- Kirk O.
- Vassilenko A.
- Klimuk D.
- Kondratenko O.
- Zalutskaya A.
- Bondarenko V.
- Mitsura V.
- Kozorez E.
- Tumash O.
- Suetnov O.
- Paduto D.
- Iljina V.
- Kummik T.
- Mshvidobadze K.
- Lanchava N.
- Goginashvili L.
- Mikiashvili L.
- Bablishvili N.
- Rozentale B.
- Zeltina I.
- Janushkevich I.
- Caplinskiene I.
- Caplinskas S.
- Kancauskiene Z.
- Wiercinska-Drapalo A.
- Thompson M.
- Kozlowska J.
- Grezesczuk A.
- Bura M.
- Knysz B.
- Inglot M.
- Garlicki A.
- Loster J.
- uiculescu D. D.
- Rakhmanova A.
- Panteleev O.
- Yakovlev A.
- Kozlov A.
- Tyukalova A.
- Vlasova Y.
- rofimov T. T.
- Kyselyova G.
- Obel N.
- Gerstoft J.
- Kronborg G.
- Payen M. C.
- abeya K. K.
- Necsoi C.
- Dabis F.
- Tsaranazy A.
- Cazanave C.
- Furrer H.
- Sagette M.
- Rickenbach M.
- Sculier D.
- Calmy A.
- Cavassini M.
- Bruno A.
- Bernasconi E.
- Hoffmann M.
- Vernazza P.
- Fehr J.
- Weber R.
- Miller R.
- Vora N.
- Cooke G.
- Mullaney S.
- Wilkins E.
- George V.
- Collini P.
- Dockrell D.
- Post F.
- Campbell L.
- Brum R.
- Mabonga E.
- Saigal P.
- Kegg S.
- Ainsworth J.
- Waters A.
- Dhar J.
- Ellis K.
- Girardi E.
- Rianda A.
- Galati V.
- Pinnetti C.
- Tommasi C.
- Lapadula G.
- Di Biagio A.
- Parisini A.
- Carbonara S.
- Angarano G.
- Purgatorio M.
- Matteelli A.
- Apostoli A.
- Miro J. M.
- Manzardo C.
- Ligero C.
- Gonzalez J.
- Martinez-Martinez J. A.
- Sanchez F.
- Knobel H.
- Salvado M.
- Lopez-Colomes J. L.
- Martinez-Lacasa X.
- Cuchi E.
- Falco V.
- Curran A.
- Tortola M. T.
- Ocana I.
- Vidal R.
- Sambeat M. A.
- Pomar V.
- Coll P.
- Pozamczer D.
- Saumoy M.
- Alcaide F.
- Cayla J.
- Moreno A.
- Millet J. P.
- Orcau A.
- Fina L.
- Romero A.
- Roldan L. L.
- Iribarren J. A.
- Ibarguren M.
- Moreno S.
- Gonzalez A.
- Miralles P.
- Aldamiz-Echevarria T.
- Losso M.
- Toibaro J.
- Gambardella L.
- Toibaro J.
- Moreno Macias L.
- Warley E.
- Tavella S.
- Garcia Messina O.
- Gear O.
- Laplume H.
- Marson C.
- Contarelia J.
- Michaan M.
- Scapellato P.
- Bartoletti B.
- Palmero D.
- Elias C.
- Cortes C.
- Crabtree B.
- Mosqueda Gomez J. L.
- Villanueva J. A.
- Gonzalez Hernandez L. A.
- Badial F.
DOIAbstract
Background: Early diagnosis of tuberculosis (TB) is important to reduce transmission, morbidity and mortality in people living with HIV (PLWH). Methods: PLWH with a diagnosis of TB were enrolled from HIV and TB clinics in Eastern Europe and followed until 24 months. Delayed diagnosis was defined as duration of TB symptoms (cough, weight-loss or fever) for ≥ 1 month before TB diagnosis. Risk factors for delayed TB diagnosis were assessed using multivariable logistic regression. The effect of delayed diagnosis on mortality was assessed using Kaplan–Meier estimates and Cox models. Findings: 480/740 patients (64.9%; 95% CI 61.3–68.3%) experienced a delayed diagnosis. Age ≥ 50 years (vs. < 50 years, aOR = 2.51; 1.18–5.32; p = 0.016), injecting d...
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