Taxonomy Driven Discovery of Polyketides fromAspergillus californicus
- Guo Y.
- Ding L.
- Ghidinelli S.
- Gotfredsen C. H.
- de la Cruz M.
- Mackenzie T. A.
- Ramos M. C.
- Sanchez P.
- Vicente F.
- Genilloud O.
- Coriani S.
- Larsen R. W.
- Frisvad J. C.
- Larsen T. O.
Publication date
January 2021
DOI Publisher
American Chemical Society (ACS)Abstract
Five new polyketides were isolated from the rare filamentous fungusAspergillus californicusIBT 16748 including calidiol A (1); three phthalide derivatives califuranones A1, A2, and B (2-4); and a pair of enantiomers (−)-calitetralintriol A (−5) and (+)-calitetralintriol A (+5) together with four known metabolites (6-9). The structures of the new products were established by extensive spectroscopic analyses including HRMS and 1D and 2D NMR. The absolute configurations of two diastereomers2and3and the enantiomers (−5) and (+5) were assigned by comparing their experimental and calculated ECD data, whereas the absolute configuration of4was proposed by analogy. Compound1showed moderate activity against methicillin-resistantStaphylococcus aureus
Add to ORKG