Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease
- di Domenico A.
- Carola G.
- Calatayud C.
- Pons-Espinal M.
- Munoz J. P.
- Richaud-Patin Y.
- Fernandez-Carasa I.
- Gut M.
- Faella A.
- Parameswaran J.
- Soriano J.
- Ferrer I.
- Tolosa E.
- Zorzano A.
- Cuervo A. M.
- Raya A.
- Consiglio A.
DOIAbstract
In this article, Consiglio and colleagues show that PD iPSC-derived astrocytes contribute to dopaminergic neurodegeneration, indicating an important role for astrocytes in the pathogenesis of Parkinson's disease. PD astrocytes display dysfunctional chaperone-mediated autophagy (CMA), impaired macroautophagy, and progressive α-synuclein accumulation. In co-culture, PD astrocytes transfer α-synuclein to vmDAns and trigger dopaminergic neuronal cell death that can be rescued by treatment with a chemical enhancement of CMA
Add to ORKG