Dermal fibrosis and cutaneous necrosis after recombinant interferon-β1a injection in a multiple sclerosis patient

The most commonly reported side-effects of recombinant interferon-β1a and 1b include local inflammatory injection site reactions, headache, fever, myalgia and a flu-like syndrome. In this case report, we describe the occurrence of cutaneous necrosis and dermal fibrosis following intramuscular interferon-β1a injections in a multiple sclerosis patient. © 2004 European Academy of Dermatology and Venereology