Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy
- Spisek, R.
- Kukreja, A.
- Chen L.-C.
- Matthews P.
- Mazumder, A.
- Vesole, D.
- Jagannath, S.
- Zebroski H.A.
- Simpson, A.J.G.
- Ritter G.
- Durie, B.
- Crowley J.
- Shaughnessy Jr. J.D.
- Scanlan, M.J.
- Gure, A.O.
- Barlogie, B.
- Dhodapkar, M.V.
DOIAbstract
Specific targets of cellular immunity in human premalignancy are largely unknown. Monoclonal gammopathy of undetermined significance (MGUS) represents a precursor lesion to myeloma (MM). We show that antigenic targets of spontaneous immunity in MGUS differ from MM. MGUS patients frequently mount a humoral and cellular immune response against SOX2, a gene critical for self-renewal in embryonal stem cells. Intranuclear expression of SOX2 marks the clonogenic CD138? compartment in MGUS. SOX2 expression is also detected in a proportion of CD138+ cells in MM patients. However, these patients lack anti-SOX2 immunity. Cellular immunity to SOX2 inhibits the clonogenic growth of MGUS cells in vitro. Detection of anti-SOX2 T cells predicts favorable ...
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