Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

Demir, Z.
Guven, E.B.
Ozbey, S.
Kazak, C.
Atalay, R.C.
Tuncbilek, M.

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Publication date

January 2015

DOI

10.1016/j.ejmech.2014.10.080

Publisher

Elsevier BV

Abstract

Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS

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Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

Abstract

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Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

Abstract

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