Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) have been documented in aged animals and may contribute to changes in hippocampal-dependent memory. Growth hormone (GH) regulates AMPA-R and NMDA-R-dependent excitatory transmission and decreases with age. Chronic GH treatment mitigates age-related cognitive decline. An in vitro CA1 hippocampal slice preparation was used to compare hippocampal excitatory transmission and plasticity in old animals treated for 6-8 months with either saline or GH. Our findings indicate that GH treatment restores NMDA-R-dependent basal synaptic transmission in old rats to young adult levels and enhances both AMPA-R-dependent basal...
The hippocampus is remarkably plastic and has the ability to modify its processes throughput the lif...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...
Cataloged from PDF version of article.Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolep...
Cataloged from PDF version of article.In rats, as in humans, normal aging is characterized by a decl...
In rats, as in humans, normal aging is characterized by a decline in hippocampal-dependent learning ...
Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging...
[eng] An age-related decline in cognitive functions and physical performance has been associated wit...
Growth hormone (GH) deficiency is associated with impaired learning and memory. One possible target ...
Growth hormone receptor knockout (GHR-KO) mice are long lived with improved health span, making this...
Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging...
The age-related decline in growth hormone is one of the most robust endocrine markers of biological ...
Growth hormone (GH) deficiency is associated with impaired learning and memory. One possible target ...
The accuracy of memory for recent events is reported to decay between young adulthood and middle age...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...
The hippocampus is remarkably plastic and has the ability to modify its processes throughput the lif...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...
Cataloged from PDF version of article.Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolep...
Cataloged from PDF version of article.In rats, as in humans, normal aging is characterized by a decl...
In rats, as in humans, normal aging is characterized by a decline in hippocampal-dependent learning ...
Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging...
[eng] An age-related decline in cognitive functions and physical performance has been associated wit...
Growth hormone (GH) deficiency is associated with impaired learning and memory. One possible target ...
Growth hormone receptor knockout (GHR-KO) mice are long lived with improved health span, making this...
Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging...
The age-related decline in growth hormone is one of the most robust endocrine markers of biological ...
Growth hormone (GH) deficiency is associated with impaired learning and memory. One possible target ...
The accuracy of memory for recent events is reported to decay between young adulthood and middle age...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...
The hippocampus is remarkably plastic and has the ability to modify its processes throughput the lif...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...
Cognitive impairments are an increasing health problem worldwide. In the developed countries, the av...