International audienceWe have compared observations of the planetary mean thermal profile and mesospheric wind velocities on the disk, obtained with our millimetric observations of CO rotational lines, to predictions from the Laboratoire de M´et´eorologie Dynamique (LMD) Mars General Circulation Model, as provided through the Mars Climate Database (MCD) numerical tool. Methods. We observed the atmosphere of Mars at CO(1-0) and CO(2-1) wavelengths with the IRAM 30-m antenna in June 2001 and November 2005. We retrieved the mean thermal profile of the planet from high and low spectral resolution data with an inversion method detailed here. High spectral resolution spectra were used to derive mesospheric wind velocities on the planetary disk. W...