Although it is known for long time that the peripheral nervous system has the capacity for self-regeneration, the molecular mechanisms by which Schwann cells and extracellular matrix (ECM) guide the injured axons to regrow along their original path, remains a poorly understood process. Due to the importance of ECM molecules during development, constitutive mutant organisms display increased lethality, therefore, conditional or inducible strategies have been used to increase the survival of the organisms and allow the study of the role of ECM proteins. In a recent report published in Neuron, Isaacman-Beck and colleagues (2015) used these pioneering genetic studies on zebrafish combined with in vivo fluorescent imaging, to investigate the mic...
After injury, axons of the peripheral nervous system (PNS) regenerate, and yet functional recovery f...
Following injury to the central nervous system (CNS), adult mammals are largely unable to regenerate...
Mammalian retinal ganglion cells (RGCs) in the central nervous system (CNS) often die after trauma t...
Axons of the peripheral nervous system have retained the remarkable ability to regenerate. However, ...
Axons of the peripheral nervous system have retained the remarkable ability to regenerate. However, ...
International audienceThe motor neurons (MN) form the ultimate route to convey the commands from the...
SummaryFunctional PNS regeneration requires injured axons to return to their original synaptic targe...
Abstract Background Understanding the cellular mechanisms regulating axon degeneration and regenerat...
BackgroundUnderstanding the cellular mechanisms regulating axon degeneration and regeneration is cru...
Vertebrate peripheral nerves can regenerate, enabling severed axons to reconnect with their original...
Following injury, peripheral nerves reestablish neuromuscular connections with their developmental t...
Vertebrate peripheral nerves can regenerate, enabling severed axons to reconnect with their original...
Synapses link neuronal populations into circuits, which in turn regulate behavior. Axon damage is a ...
Neural damage is a devastating outcome of physical trauma. The glia are one of the main effectors of...
Neural damage is a devastating outcome of physical trauma. The glia are one of the main effectors of...
After injury, axons of the peripheral nervous system (PNS) regenerate, and yet functional recovery f...
Following injury to the central nervous system (CNS), adult mammals are largely unable to regenerate...
Mammalian retinal ganglion cells (RGCs) in the central nervous system (CNS) often die after trauma t...
Axons of the peripheral nervous system have retained the remarkable ability to regenerate. However, ...
Axons of the peripheral nervous system have retained the remarkable ability to regenerate. However, ...
International audienceThe motor neurons (MN) form the ultimate route to convey the commands from the...
SummaryFunctional PNS regeneration requires injured axons to return to their original synaptic targe...
Abstract Background Understanding the cellular mechanisms regulating axon degeneration and regenerat...
BackgroundUnderstanding the cellular mechanisms regulating axon degeneration and regeneration is cru...
Vertebrate peripheral nerves can regenerate, enabling severed axons to reconnect with their original...
Following injury, peripheral nerves reestablish neuromuscular connections with their developmental t...
Vertebrate peripheral nerves can regenerate, enabling severed axons to reconnect with their original...
Synapses link neuronal populations into circuits, which in turn regulate behavior. Axon damage is a ...
Neural damage is a devastating outcome of physical trauma. The glia are one of the main effectors of...
Neural damage is a devastating outcome of physical trauma. The glia are one of the main effectors of...
After injury, axons of the peripheral nervous system (PNS) regenerate, and yet functional recovery f...
Following injury to the central nervous system (CNS), adult mammals are largely unable to regenerate...
Mammalian retinal ganglion cells (RGCs) in the central nervous system (CNS) often die after trauma t...