Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course
- Cortese R.
- Battaglini M.
- Parodi F.
- Stromillo M. L.
- Portaccio E.
- Razzolini L.
- Giorgio A.
- Sormani M. P.
- Amato M. P.
- De Stefano N.
DOIAbstract
The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We found that global brain and gray matter (GM) atrophy changes were milder in MS patients with long-standing disease (⩾30 years from onset) and favorable (no/minimal disability) clinical course than in sex-age-matched disable MS patients, independently of lesions accumulation. Data showed that different trajectories of volume changes, as reflected by mild GM atrophy, may characterize patients with long-term favorable evolution
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