Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the recent data highlighting an association between COVID-19 and diabetes, a detailed analysis aimed at evaluating ACE2 expression pattern distribution in human pancreas is still lacking. Here, we took advantage of INNODIA network EUnPOD biobank collection to thoroughly analyze ACE2, both at mRNA and protein level, in multiple human pancreatic tissues and using several methodologies. Using multiple reagents and antibodies, we showed that ACE2 is expressed in human pancreatic islets, where it is preferentially expressed in subsets of insulin producing β-cells. ACE2 is a...
The World Health Organization declared the COVID-19 epidemic a public health emergency of internatio...
Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the ...
Angiotensin-converting enzyme 2 (ACE2), first discovered in 2000, serves as an important counterregu...
Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2...
Several studies demonstrated that COVID-19 has a more severe outcome in patients with diabetes; in a...
Aims: Angiotensin I-converting enzyme type 2 (ACE2), a pivotal SARS-CoV-2 receptor, has been shown t...
Evidence suggests an association between severe acute respiratory syndrome-cornavirus-2 (SARS-CoV-2)...
Emerging evidence points toward an intricate relationship between the pandemic of coronavirus diseas...
Infection-related diabetes can arise as a result of virus-associated β-cell destruction. Clinical da...
Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onse...
Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and societ...
Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onse...
Emerging evidence points towards an intricate relationship between the pandemic coronavirus disease ...
Increased expression of pulmonary ACE2, the SARS-CoV-2 receptor, could contribute to increased infec...
International audienceThe etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic ...
The World Health Organization declared the COVID-19 epidemic a public health emergency of internatio...
Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the ...
Angiotensin-converting enzyme 2 (ACE2), first discovered in 2000, serves as an important counterregu...
Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2...
Several studies demonstrated that COVID-19 has a more severe outcome in patients with diabetes; in a...
Aims: Angiotensin I-converting enzyme type 2 (ACE2), a pivotal SARS-CoV-2 receptor, has been shown t...
Evidence suggests an association between severe acute respiratory syndrome-cornavirus-2 (SARS-CoV-2)...
Emerging evidence points toward an intricate relationship between the pandemic of coronavirus diseas...
Infection-related diabetes can arise as a result of virus-associated β-cell destruction. Clinical da...
Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onse...
Abstract The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and societ...
Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onse...
Emerging evidence points towards an intricate relationship between the pandemic coronavirus disease ...
Increased expression of pulmonary ACE2, the SARS-CoV-2 receptor, could contribute to increased infec...
International audienceThe etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic ...
The World Health Organization declared the COVID-19 epidemic a public health emergency of internatio...
Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the ...
Angiotensin-converting enzyme 2 (ACE2), first discovered in 2000, serves as an important counterregu...