Asymmetric synthesis of mechanically planar chiral rotaxanes and topologically chiral catenanes has been a long-standing challenge in organic synthesis. Recently, an excellent strategy was developed based on diastereomeric synthesis of rotaxanes and catenanes with mechanical chirality followed by removal of the chiral auxiliary. On the other hand, its enantioselective approach has been quite limited. Here, we report enantioselective preparation of mechanically planar chiral rotaxanes by kinetic resolution of the racemates via remote asymmetric acylation of a hydroxy group in the axis component, which provides an unreacted enantiomer in up to >99.9% ee in 29% yield (the theoretical maximum yield of kinetic resolution of racemate is 50%). ...
Chirality typically arises in molecules because of a rigidly chiral arrangement of covalently bonded...
Although chiral mechanically interlocked molecules (MIMs) have been synthesised and studied, enantio...
Chiral interlocked molecules in which the mechanical bond provides the sole stereogenic unit are typ...
Rotaxanes are interlocked molecules in which a molecular ring is trapped on a dumbbell-shaped axle b...
ABSTRACT: We describe the first method for produc-tion of mechanically planar chiral rotaxanes in ex...
We describe the first method for production of mechanically planar chiral rotaxanes in excellent ena...
Mechanically interlocked molecules have been of interest to chemists since the 1960s. Recent synthet...
Rotaxanes can display molecular chirality solely due to the mechanical bond between the axle and enc...
Rotaxanes consisting of achiral axle and achiral ring components can possess supramolecular chiralit...
Active-template auxiliary methodologies have previously been developed for the stereoselective synth...
Chiral interlocked molecules in which the mechanical bond provides the sole stereogenic unit are typ...
A chiral [2]rotaxane in which the asymmetry is derived from the way in which the two components are ...
Mechanically interlocked molecules are very interesting compounds for their architecture. The core o...
Active-template auxiliary methodologies have previously been developed for the stereoselective synth...
We exploit a reversible acid-base triggered molecular shuttling process to switch an appropriately d...
Chirality typically arises in molecules because of a rigidly chiral arrangement of covalently bonded...
Although chiral mechanically interlocked molecules (MIMs) have been synthesised and studied, enantio...
Chiral interlocked molecules in which the mechanical bond provides the sole stereogenic unit are typ...
Rotaxanes are interlocked molecules in which a molecular ring is trapped on a dumbbell-shaped axle b...
ABSTRACT: We describe the first method for produc-tion of mechanically planar chiral rotaxanes in ex...
We describe the first method for production of mechanically planar chiral rotaxanes in excellent ena...
Mechanically interlocked molecules have been of interest to chemists since the 1960s. Recent synthet...
Rotaxanes can display molecular chirality solely due to the mechanical bond between the axle and enc...
Rotaxanes consisting of achiral axle and achiral ring components can possess supramolecular chiralit...
Active-template auxiliary methodologies have previously been developed for the stereoselective synth...
Chiral interlocked molecules in which the mechanical bond provides the sole stereogenic unit are typ...
A chiral [2]rotaxane in which the asymmetry is derived from the way in which the two components are ...
Mechanically interlocked molecules are very interesting compounds for their architecture. The core o...
Active-template auxiliary methodologies have previously been developed for the stereoselective synth...
We exploit a reversible acid-base triggered molecular shuttling process to switch an appropriately d...
Chirality typically arises in molecules because of a rigidly chiral arrangement of covalently bonded...
Although chiral mechanically interlocked molecules (MIMs) have been synthesised and studied, enantio...
Chiral interlocked molecules in which the mechanical bond provides the sole stereogenic unit are typ...