Infection dynamics of Nosema ceranae in honey bee midgut and host cell apoptosis

Nosema ceranae is an intracellular microsporidian parasite that infects epithelial cells of the honey bee (Apis mellifera) midgut. Previous studies have shown that Nosema may alter cell renewal and apoptosis in honey bees. We found that the amount of apoptotic cells progressively declines from the anterior towards posterior regions of the midgut in Nosema-infected sensitive bees. There was no such pattern in the infected Nosema tolerant honey bees and controls. These data provide additional evidence that N. ceranae appears to alter apoptosis in its host cells for its own advantage.The Deutsche Forschungsgemeinschaft through the priority program “Host-Parasite Coevolution – Rapid Reciprocal Adaptation and its Genetic Basis” (SPP 1399). Grant number MO373/26-2.http://www.elsevier.com/locate/jip2019-05-01hj2018Zoology and Entomolog