High-fat diet attenuates Alzheimer's disease-related pathology and cognitive impairment in a transgenic mouse model

This study investigated the effect of high-fat diet consumption on Alzheimer's disease-related pathology in the Tg6799 mouse model. We found that high-fat diet attenuates Alzheimer's disease-related pathology and cognitive dysfunction in Tg6799 mice and propose decreased beta-amyloid deposition due to improved autophagic-lysosomal flux as a potential, underlying mechanism