Associations between HIV viremia during antiretroviral therapy and cardiovascular disease
- Elvstam, Olof
- Marrone, Gaetano
- Engström, Gunnar
- Nilsson, Peter M
- Carlander, Christina
- Treutiger, Carl Johan
- Gisslén, Magnus
- Björkman, Per
DOIAbstract
OBJECTIVE: To investigate the association between HIV viremia exposure during antiretroviral therapy (ART) and cardiovascular disease (CVD) risk.DESIGN: Nationwide observational cohort.METHODS: Participants (age > 15 years) from the Swedish nationwide InfCareHIV register initiating ART 1996-2017 were categorized in a time-updated manner into four viremia categories, starting from 12 months after ART initiation: suppression (<50 copies/ml), low-level viremia (50-199 copies/ml and 200-999 copies/ml, respectively), and high-level viremia (≥1000 copies/ml). In addition, cumulative viremia was estimated as the area under the log viral load (VL) curve. Proportional subhazard models adjusted for sex, age, pre-ART CD4 and VL, injection drug use, an...
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