A global perspective of the current state of heavy metals contamination in road dust

16 Heavy metals are persistent and bio-accumulative, and pose potential risk to human health and 17 ecosystem. We reviewed the current state of heavy metals contamination, the ecotoxicological 18 and human health risk of heavy metals reported in urban road dust from various cities in different 19 continents (Asia, Europe, Africa, America, and Australia). We compared and synthesized the 20 findings on the methods related to sample collection, extraction, analytical tools of heavy metals, 21 their concentrations, level of contamination, ecological risk, non-carcinogenic risk, and 22 carcinogenic risk in road dust. Concentrations of Pb, Zn, Cu, Ni, Cd, Cr, Mn, and Fe were found 23 to be higher than their background values in soil. As expected, the contamination levels of the 24 heavy metals varied extensively among cities, countries, continents, and periods. A high level of 25 contamination is observed for Pb and Cd in road dust due to operating leaded gasoline and the old 26 vehicle population. The highest Zn contamination was observed from road dust in Europe, 27 followed by Asia, Africa, Australia, and America (North America and South America). Cu 28 contamination and the pollution load index (PLI) is found to be the highest in Europe and lowest 29 in Africa, with in-between values of PLI in American and African cities. The potential ecological 30 risk on different continents was observed highest in Asia, followed by Europe, Australia, America, 31 and Africa. A comparative assessment of non-carcinogenic risk for children indicated that 32 Australia is a most susceptible country due to high heavy metals exposure in road dust, followed 33 by Asia. However, there is no susceptible risk in European, African and American cities. We did 34 not observe any potential risk to adults due to non-carcinogenic metals. Carcinogenic risk to all 35 age groups was within the threshold limit range for all the regions worldwide. 3