Psychosocial wellbeing and health-related quality of life in a UK population with Usher syndrome

Objectives: To determine whether psychosocial wellbeing is associated with the health-related quality of life (HRQOL) of people with Usher syndrome. Setting: The survey was advertised online and through deafblind-related charities, support groups and social groups throughout the UK. Participants: 90 people with Usher syndrome took part in the survey. Inclusion criteria are having a diagnosis of Usher syndrome, being 18 or older and being a UK resident. Primary and secondary outcome measures: All participants took part in a survey that measured depressive symptoms, loneliness and social support ( predictors) and their physical and mental HRQOL (outcomes). Measured confounders included agerelated, sex-related and health-related characteristics. Hierarchical multiple linear regression analyses examined the association of each psychosocial wellbeing predictor with the physical and mental HRQOL outcomes while controlling for confounders in a stepwise manner. Results: After adjusting for all confounders, psychosocial well-being was shown to predict physical and mental HRQOL in our population with Usher syndrome. Increasing depressive symptoms were predictive of poorer physical (β=−0.36, p<0.01) and mental (β=−0.60, p<0.001) HRQOL. Higher levels of loneliness predicted poorer mental HRQOL (β=−0.20, p<0.05). Finally, increasing levels of social support predicted better mental HRQOL (β=0.19, p