The mechanism of induction of peroxisome proliferation by xenobiotics was investigated. Firstly, the evidence for a soluble cytosolic receptor was evaluated. No specific displaceable binding of [[3]H]-nafenopin or [[3]H]-ciprofibrate to rat liver subcellular fractions was observed. It was concluded that there is no evidence for a cytosolic receptor for the xenobiotic peroxisome proliferators. The time course of induction of several parameters were determined at the molecular, protein and enzyme activity levels, following a single i. p. dose of sodium clofibrate. Cytochrome P-450 IVA1 and lauric acid hydroxylase activity showed a biphasic response to sodium clofibrate, with the major peak occurring between 18 and 24 hours post dose. The mino...
Certain lipid-regulating agents induce hepatomegaly, hepatic peroxisome proliferation and hepatocarc...
The induction of hepatic peroxisomal /3-oxidation and the peroxisomal bifunctional enzyme (PBE) by t...
Changes in the activities of two peroxisomal enzymes (catalase and thiolase), some parameters relate...
1. Species differences in elements of the peroxisome proliferator domain (PPD), including the cytoch...
Induction of the cytochrome P-450 mixed-function oxidase and specifically the cytochrome P-450 IVA1 ...
An investigation into the early cell biology changes in response to non-genotoxic carcinogens was ca...
The main area of interest of this dissertation was to establish the mechanism of action of the hypol...
The potential inducing ability of azole antifungal drugs on cytochrome P450 isozymes, in particular ...
International audiencePeroxisome proliferators (PPs) are a class of rodent nongenotoxic hepatocarcin...
chloro-6-(2,3-xylidino)-2-pyrimidinylthio(-β-hydroxyethyl) acetamide]), methyl clofenapate ...
Graduation date: 1981In order to determine the total number of cytochrome P-450 isozymes\ud present ...
Peroxisome proliferators are structurally diverse compounds that include industrial chemicals, envir...
dissertationThe nature of extent of drug metabolizing enzyme induction by exogenous compounds is oft...
The isolation and purification of two major phenobarbitone-induced hepatic cytochromes P-450 from ma...
The pregnane X receptor (PXR) interacts with a vast array of structurally dissimilar chemicals and c...
Certain lipid-regulating agents induce hepatomegaly, hepatic peroxisome proliferation and hepatocarc...
The induction of hepatic peroxisomal /3-oxidation and the peroxisomal bifunctional enzyme (PBE) by t...
Changes in the activities of two peroxisomal enzymes (catalase and thiolase), some parameters relate...
1. Species differences in elements of the peroxisome proliferator domain (PPD), including the cytoch...
Induction of the cytochrome P-450 mixed-function oxidase and specifically the cytochrome P-450 IVA1 ...
An investigation into the early cell biology changes in response to non-genotoxic carcinogens was ca...
The main area of interest of this dissertation was to establish the mechanism of action of the hypol...
The potential inducing ability of azole antifungal drugs on cytochrome P450 isozymes, in particular ...
International audiencePeroxisome proliferators (PPs) are a class of rodent nongenotoxic hepatocarcin...
chloro-6-(2,3-xylidino)-2-pyrimidinylthio(-β-hydroxyethyl) acetamide]), methyl clofenapate ...
Graduation date: 1981In order to determine the total number of cytochrome P-450 isozymes\ud present ...
Peroxisome proliferators are structurally diverse compounds that include industrial chemicals, envir...
dissertationThe nature of extent of drug metabolizing enzyme induction by exogenous compounds is oft...
The isolation and purification of two major phenobarbitone-induced hepatic cytochromes P-450 from ma...
The pregnane X receptor (PXR) interacts with a vast array of structurally dissimilar chemicals and c...
Certain lipid-regulating agents induce hepatomegaly, hepatic peroxisome proliferation and hepatocarc...
The induction of hepatic peroxisomal /3-oxidation and the peroxisomal bifunctional enzyme (PBE) by t...
Changes in the activities of two peroxisomal enzymes (catalase and thiolase), some parameters relate...