A Large Retrospective Assessment of Voriconazole Exposure in Patients Treated with Extracorporeal Membrane Oxygenation.
- Van Daele, Ruth
- Bekkers, Britt
- Lindfors, Mattias
- Broman, Lars Mikael
- Schauwvlieghe, Alexander
- Rijnders, Bart
- Hunfeld, Nicole G M
- Juffermans, Nicole P
- Taccone, Fabio Silvio
- Coimbra Sousa, Carlos Antônio
- Jacquet, Luc-Marie
- Laterre, Pierre-François
- Nulens, Eric
- Grootaert, Veerle
- Lyster, Haifa
- Reed, Anna
- Patel, Brijesh
- Meersseman, Philippe
- Debaveye, Yves
- Wauters, Joost
- Vandenbriele, Christophe
- Spriet, Isabel
DOIAbstract
BACKGROUND: Voriconazole is one of the first-line therapies for invasive pulmonary aspergillosis. Drug concentrations might be significantly influenced by the use of extracorporeal membrane oxygenation (ECMO). We aimed to assess the effect of ECMO on voriconazole exposure in a large patient population. METHODS: Critically ill patients from eight centers in four countries treated with voriconazole during ECMO support were included in this retrospective study. Voriconazole concentrations were collected in a period on ECMO and before/after ECMO treatment. Multivariate analyses were performed to evaluate the effect of ECMO on voriconazole exposure and to assess the impact of possible saturation of the circuit's binding sites over time. RESULTS:...
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