A study of the influence of co-processed dry binder type on the properties of oraly disintegrating tablets with the drugs ibuprofen and paracetamol.

Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Consultant: Mgr. Thao Tranová Student: Michaela Víšková Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with the drugs ibuprofen and paracetamol. This thesis deals with the study of orally disintegrating tablets containing co-processed dry binders Ludiflash® , Prosolv® ODT G2 and Parteck® ODT with analgesics ibuprofen and paracetamol. The tablets also include magnesium stearate as a lubricant and sucralose as a sweetener at a concentration of 1%. The energy profile of the compression process, tablet tensile strength, friability, porosity, wetting time, water absorption ratio and disintegration time of the tablets are evaluated. Tableting material with Prosolv® ODT G2 shows the lowest value of pre-compression energy, drugs increase it. Furthermore, it shows the highest value of compression energy that drugs reduce. Prosolv® ODT G2 and Parteck® ODT placebo tablets have higher tensile strength than Ludiflash® placebo tablets. Drugs reduce tablet tensile strength, paracetamol more significantly. Placebo tablets meet the requirement for friability (up to 1 %), whereas in the case..