A study of the influence of co-processed dry binder type on the properties of oraly disintegrating tablets with the drugs domperidone and lisinopril.

Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Consultant: Mgr. Thao Tranová Student: Kateřina Jáglová Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with the drugs domperidone and lisinopril The study deals with the influence of the type of co-processed dry binder on the compressibility of directly compressible tableting materials and the properties of orodispersible tablets containing the drugs domperidone and lisinopril. The tested co- processed dry binders are Ludiflash ® , Prosolv ® ODT G2 and Parteck ® ODT. The tablets further contain 1% sucralose as a sweetener and 1% magnesium stearate as a lubricant. The tablets are compressed by a compression force of 3 kN. The compressibility is evaluated by the energy profile of the compression process. Tensile strength, friability, wetting time, disintegration time, and porosity of tablets are tested. In the group of placebo, Parteck ® ODT showed the highest total energy of compression, whereas Prosolv ® ODT G2 showed the lowest values. The values of this energy decreased with the addition of drugs in all formulations, with domperidone having more significant effect...