Preparation of spray-dried powder containing active substance, chitosan and surfactant

7 2 ABSTRACT Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Helena Kubová Title of Thesis: Preparation of spray-dried powder containing active substance, chitosan and surfaktant The main of this work was to prepare spray-dried powder containing meloxicam, chitosan and CTAB as surfactant. Spray drying is a method used to increase the bioavailability of poorly soluble drugs. Surfactants are substances that increase the solubility of drugs by the mechanism of micellar solubilization. Samples with different concentrations of meloxicam and constant amount of CTAB and chitosan used as a carrier were prepared. Three different temperatures, 170 řC, 190 řC and 210 řC were used for spray drying. The effectiveness of CTAB on properties of prepared particles and on the drug release from the samples was evaluated. The 1,4 mm diameter nozzle was used for spray drying. Optical microscopy and SEM were used to evaluate the appearance of prepared particles and the thermal characteristics were evaluated by DSC. The amount of drug released was evaluated using dissolution test. The particles of obtained powder had an irregular plate-like shape corresponding to chitosan particles. Spherical particles of meloxicam with CTAB..