The application of Terbinafine in the treatment of Mycosis

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Mgr. Lenka Burgetová Consultant: Doc. RNDr. Milan Dittrich, CSc. Title of Thesis: The application of Terbinafine in the treatment of Mycosis The theoretical part of this thesis includes an overview of the use of nanoparticles in the treatment of infectious diseases. Some metal nanoconstructs are known to possess antimicrobial activities. Nanoparticles offer significant benefits but at the same time there are some disadvantages compared to conventional antimicrobial agents. Poly(lactic-co-glycolic acid) (PLGA) has been developed to act as a drug delivery system in various biomedical applications. As a biodegradable polymer, its hydrolysis leads to metabolite monomers, causing minimal systemic toxicity. The main focus of this thesis is on experimental part. Nanoparticles were prepared by the emulsion solvent distribution and evaporation method. The internal part of the emulsion contains polyesters of aliphatic hydroxyacids which were synthesized at my academic supervisor's departmental laboratory. It was found that these acids have both suitable constitution and molecular weight. Binary mixtures were prepared from these carriers or ternary mixtures by adding Terbinafine as a model..