Voltammetric Determination of Flutamide at Screen-Printed Carbon Electrodes

The paper deals with the electrochemical behaviour of flutamide at screen-printed carbon electrodes (SPCE) with the aim of optimizing conditions for their practical use in the in situ analyses. A stability of stock solution was verified and confirmed primarily. Then, an influence of pH, stirring time and flutamide concentration in the analyzed solution on the voltammetric behavior of flutamide were systematically studied using DC voltammetry and differential pulse voltammetry at SPCE. One well-developed voltammetric peak of flutamide was detected in the whole pH region investigated. The time of stirring appears to be of crucial importance for the result of measurements at all pHs. The longer time of stirring of the solution prior to measurements, the higher is the flutamide peak. Therefore, the time of stirring was set constant for the rest of measurements. The optimum conditions for voltammetric determination have been found in Britton-Robinson buffer pH 7.0 - methanol (9:1) for both DCV and DPV at SPCE. Concentration dependences were found to be linear for the range 1·10-6 - 1·10-4 mol·dm-3 and evaluable (but not reliable) up to 1·10-7 mol·dm-3 . Reached limits of quantification were 6·10-7 mol·dm-3 for DCV at SPCE and 8·10-7 mol·dm-3 for DPV at SPCE. The determination of flutamide in..