Pyrazine derivatives as potential drugs I

Title of diploma thesis: Pyrazine derivates as potential drugs I. Review of tuberculosis therapy and modern research were presented in this diploma thesis. Novel pyrazine derivates connected via CO-NH-NH- bridge with substituted phenyl derivates were synthesized. Novel structures were characterized by melting points, TLC, IR, 1H and 13C NMR. This set was put through in vitro biological evaluation. Log P and Clog P were also calculated and were compared with novel synthesized structures