Copper reducing effects of flavones

Charles University in Prague Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical botanic and ecology Candidate: Mgr. Markéta Jeřábková Consultant: PharmDr. Jana Karlíčková, Ph.D. Title of Thesis: Copper reducing effects of flavones Free radicals are commonly present in our organism, however, in case of their accumulation it could cause many diseases. Copper is an important trace element which is essential for many biological processes. On the other hand, copper can catalyze processes which produce damaging radicals. Flavonoids are polyphenolic compounds with many biological effects. The most important is antioxidant activity which protects us from free radicals. Flavonids can also have a prooxidant effect. This thesis was focused on a detection of the reducing activity of flavones (mosloflavone, luteolin, apigenin, crysin, diosmin, 5-hydroxyflavone, baicalin, baicalein, negletein, apigenin-7-glucoside) at different pH. A reducing activity of surveyed flavones was taken by the methodics of spectrophotometric analysis with the use of a selective indicator of cuprous ionts formed in bathocuproinedisulfonic acid disodium salt at different pH. A reducing activity depends on the structure of flavones and pH environment. From the definition of the relation between the structure of a flavone..