Current possibilities of the treatment of psoriasis

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Martin Zápotočný Supervisor: Doc. MUDr. Radomír Hrdina, CSc. Title of diploma thesis: Current possibilities of treatment of psoriasis Psoriasis is an uninfectious disease with a genetic predisposition. There are several types of psoriasis. Therapy is heterogenous with a different efficiency. A topical, physical and systemic treatments are used. Topical treatment is a basic treatment for psoriasis. There are keratolytics, emollients, topical corticosteroids, whose prolonged use may cause adverse effects. A vitamin D3 analogue, retinoids and cignoline are also parts of topical treatment. Physical treatment, mainly phototherapy, has thanks to its unique photobiological effect unsubstituable role in a psoriasis treatment. Recently phototherapy and photochemotherapy have been classified on the same level as systemic treatment. For cases that do not respond on standard local treatment and phototherapy, systemic treatment is reserved. We can differ drugs of the 1st line: acitretin, cyclosporine A, methotrexate and drugs of the 2nd line, that are biologics. Biopharmaceuticals present safer and more accurate interference into the pathophysiological processes of psoriasis. The aim of this..