A study of the properties of tablets made of dibasic calcium phosphate dihydrate.

This thesis deals with the study of properties of the tablets from calcium hydrogen phosphate dihydrate (Emcompress® ) with Vivasol in concentration 1 or 2 % and lubricants, their concentration was 0,5 or 1 %. Then the properties of tablets from Emcompress with Prosolv in ratio 1:1 and 3:1 without or with 0,5 or 1 % of lubricants were studied. The lubricants were magnesium stearate and sodium stearyl fumarate (Pruv). The tablets with Vivasol were compressed with a force of 10, 12 and 14 kN, the others with a force of 6, 8 and 10 kN. The tensile strenght and the disintegration time were tested. Whereas tensile strenght of tablets with Vivasol was increased with increasing compression force, independently on concentration or type of lubricant, the disintegration time did not increase with compression force and it was shorter with increasing concentration of Vivasol, mainly when magnesium stearat was added. The tensile strenght of tablets from Emcompress-Prosolv 1:1 was higher than of tablets from Emcompress-Prosolv 3:1 and it incereased with compression force. The lubricants decreased tensile strenght much more for tablets from Emcompress-Prosolv 1:1 directly proportional with increasing concentration of lubricants. The shortest disintegration time had the tablets from mixture of dry binders, without..