Study of a New Mixed Dry Binder based spray-dried Lactose and Microcrystalline Cellulose

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Candidate Mgr. Pavla Šináglová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of Thesis Study of a new mixed dry binder based spray-dried lactose and microcrystalline cellulose The aim of this study was to compare compressibility and tablet disintegration time of tablets from co-procesed dry binder Disitequik™ MCC and physical mixture of dry binders containing spray-dried lactose FlowLac® 100 and microcrystalline cellulose Microcel® MC-102 in ratios of 1:9, 2:8 and 3:7. Lubricants magnesium stearate and poloxamer 407 at concentrations of 1% and 2% were added to the mixtures. Compressibility was evaluated using the energy profile of the compression and tenile strength of tablets. The tablets were prepared on the material testing device T1-FRO50 TS.S1K Zwick / Roell. Disitequik™ MCC had a stronger tablet with a longer disintegration time than the tablets from the physical mixtures of spray-dried lactose with microcrystalline celulose. The tablets from Disitequik™ MCC show higher values of total energy pressing, due to higher levels of energy stored in the tablets and higher plasticity